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JPS014

SKU: orb1982927

Description

JPS014 is a benzamide-based PROTAC that recruits the VHL E3 ligase to selectively degrade HDAC1/2. This degradation alters gene expression and induces apoptosis in HCT116 cells, making it a valuable tool for studying HDAC biology and targeted protein degradation in cancer research models.

Research Area

Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number2669785-76-4
MW854.07
FormulaC46H59N7O7S
SMILESCc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCOCC(=O)Nc2ccc(cc2)C(=O)Nc2ccccc2N)C(C)(C)C)cc1
TargetOthers

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

Protocol Information