JPC0661

SKU: orb3175196

Description

JPC0661 is a direct and allosteric inhibitor of ΔFOSB. It inhibits the binding of ΔFOSB/JUND and ΔFOSB to DNA with a micromolar IC50 value (9-52 μM), and directly suppresses ΔFOSB-mediated transcription in vitro with an IC50 of 0.82 μM. In vivo, JPC0661 notably reduces the occupancy of ΔFOSB at genomic AP1 sites. JPC0661 disrupts the formation of the ΔFOSB/JUND-DNA complex by binding to a novel groove outside the ΔFOSBDNA binding cleft. JPC0661 is applicable in Alzheimer's disease research.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 30479-81-3
• MW: 347.35
• Formula: C₁₅H₁₃N₃O₅S
• SMILES: O=C1N(N=C(N)C1)C2=CC=C(OC=3C=CC=CC3)C(=C2)S(=O)(=O)O
• Target: DNA/RNA Synthesis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

DNA/RNA Synthesis