JNK3/Wnt/β-catenin modulator-1

SKU: orb3210385

Description

JNK3/Wnt/β-catenin modulator-1 is a blood-brain barrier-penetrating inhibitor of JNK3 and an activator of the Wnt/β-catenin pathway. It reduces the generation of Aβ1-42 and the production of reactive oxygen species (ROS). This compound inhibits the activation of JNK and Puma, promotes the expression of Beclin-1, and downregulates GSK-3β and BACE1 expression, thereby activating the Wnt/β-catenin signaling pathway. JNK3/Wnt/β-catenin modulator-1 improves cognition and memory, alleviates neuropathological damage, and maintains structural integrity of hippocampal pyramidal cells and cortical neurons. It is applicable in Alzheimer’s disease research.

Key Properties

• Target: Wnt/beta-catenin,Beta Amyloid,GSK-3,Beta-Secretase,ROS,Autophagy,JNK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Wnt/beta-catenin,Beta Amyloid,GSK-3,Beta-Secretase,ROS,Autophagy,JNK