JNK3 inhibitor-9

SKU: orb2945364

Description

JNK3inhibitor-9 (Compound 24a) is a brain-penetrant, selective JNK3 inhibitor (IC50=12 nM) that also potently inhibits GSK3α/β, reducing phosphorylation of Tau, c-Jun, and APP. It demonstrates neuroprotective effects against Aβ1-42 toxicity in cellular models, supporting its research application in Alzheimer's disease and related tauopathies.

Research Area

Neuroscience, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• MW: 457.528
• Formula: C₂₅H₂₇N₇O₂
• SMILES: C1C[C@H](CN(C1)C(=O)C2CC2)NC3=NC=CC(=N3)N4C=C(C(=N4)C(=O)N)/C=C/C5=CC=CC=C5
• Target: JNK,Beta Amyloid,GSK-3

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172676869