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JNK3-IN-11

SKU: orb3211353

Description

JNK3-IN-11 is a selective JNK3 inhibitor with an IC50 of 2.08 nM. It binds to the ATP binding pocket of JNK3, forming a conserved hydrogen bond with Met149 and a water-mediated hydrogen bond with Lys93. JNK3-IN-11 inhibits TGF-β1-induced c-Jun phosphorylation, reduces pro-fibrotic markers COL1A1 and PAI-1, restores E-cadherin expression, and protects against podocyte injury. This compound is applicable for chronic kidney disease research.

Images & Validation

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JNK3-IN-11

Key Properties

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TargetCadherin,JNK,PAI-1

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Gene Symbol
Cadherin,JNK,PAI-1

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