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JNK2/MKK7 PPI-IN-1

SKU: orb3210993

Description

JNK2/MKK7 PPI-IN-1 is an orally active inhibitor of JNK2, with an IC50 of 0.99 μM and a Kd of 81.6 μM. It inhibits JNK2 kinase activity, disrupts the JNK2-MKK7 protein-protein interaction, and reduces the phosphorylation of c-Jun. Additionally, JNK2/MKK7 PPI-IN-1 suppresses LPS-induced overexpression of inflammatory cytokines IL-6 and TNF-α, and can be utilized in research related to acute lung injury.

Images & Validation

Key Properties

TargetJNK,Interleukin,TNF,p38 MAPK

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information