JNK-IN-17

SKU: orb3175173

Description

JNK-IN-17 (Compound 9J) is a selective and potent inhibitor of JNK, exhibiting IC50 values of 0.039 μM for JNK1 and 0.079 μM for JNK3. It effectively inhibits c-Jun phosphorylation in Streptozotocin-induced INS-1 pancreatic β cells, with an IC50 of 0.082 μM. JNK-IN-17 shows inhibition rates of ≤ 33% for the four major P450 isoforms (2C9, 2D6, 3A4, 1A2) in human liver microsomes, indicating a relatively low risk of drug interactions. This compound can be utilized in research on neurological and metabolic disorders, including Parkinson's disease.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1128096-58-1
• MW: 501.55
• Formula: C₂₈H₂₃N₉O
• SMILES: N#CC1=CC(=CC(=C1)N2CCOCC2)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5N=C(N=C5)C=6C=NC=CC6
• Target: JAK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

JAK