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JNK-IN-14
Catalog Number: orb2277712
| Catalog Number | orb2277712 |
|---|---|
| Category | Small Molecules |
| Description | JNK-IN-14 is a potent inhibitor of JNK with IC50 values of 1.81 nM for JNK1, 12.7 nM for JNK2, and 10.5 nM for JNK3. It induces early-stage apoptosis, arrests cell population at the G2/M phase, and moderately inhibits beclin-1 production in K562 leukemia cells, demonstrating greater inhibitory efficacy than SP600125. [1] |
| Purity | 98.00% |
| MW | 521.63 |
| Formula | C27H31N5O4S |
| Biological Activity | JNK-IN-14 is a potent inhibitor of JNK with IC50 values of 1.81 nM for JNK1, 12.7 nM for JNK2, and 10.5 nM for JNK3. It induces early-stage apoptosis, arrests cell population at the G2/M phase, and moderately inhibits beclin-1 production in K562 leukemia cells, demonstrating greater inhibitory efficacy than SP600125. [1] |
| Storage | -20°C |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
