JNK-IN-14

SKU: orb2277712

Description

JNK-IN-14 is a potent and selective JNK inhibitor with single-digit nanomolar IC50 values against JNK1, JNK2, and JNK3 isoforms. It demonstrates robust cellular activity by inducing apoptosis, causing G2/M phase arrest, and modulating autophagy-related proteins like beclin-1 in leukemia cell models, showing superior potency to SP600125. This inhibitor is a valuable chemical probe for researching JNK signaling in oncology, neurology, and cellular stress responses both in vitro and in vivo.

Research Area

Metabolism Research, Signal Transduction

Key Properties

• MW: 521.63
• Formula: C₂₇H₃₁N₅O₄S
• Target: Cytochromes P450,JNK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Cytochromes P450,JNK