JNK-IN-12

SKU: orb2278057

Description

JNK-IN-12 (compound P2) is a mitochondrial-targeted JNK inhibitor with an IC50 value of 66.3 nM, consisting of a mitochondrial-specific cell-penetrating peptide linked to SP600125, a selective JNK inhibitor. It selectively impedes mitochondrial JNK phosphorylation without inhibiting nuclear JNK signaling and has shown efficacy in ameliorating Parkinson's disease (PD) symptoms in both in vitro and in vivo studies.

Research Area

Signal Transduction

Key Properties

• MW: 1091.35
• Formula: C₅₆H₈₂N₁₆O₇
• Target: JNK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

JNK