JNK-1-IN-4

SKU: orb2664976

Description

JNK-1-IN-4 (Compound E1) is a potent, bioavailable pan-JNK inhibitor (IC50s: 2.7-19.0 nM) that suppresses c-Jun phosphorylation and TGF-β1-induced EMT markers in vitro. It demonstrates significant antifibrotic efficacy in a bleomycin-induced mouse model of pulmonary fibrosis, supporting its use in fibrotic disease research.

Research Area

Signal Transduction

Key Properties

• CAS Number: 3047795-60-5
• MW: 501.38
• Formula: C₂₂H₂₅BrN₆O₃
• SMILES: O=C(N)C1=CC(OCCN(C)C)=CC=C1NC2=NC(=NC=C2Br)NC3=CC=C(OC)C=C3
• Target: JNK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172652601