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JNJ-42041935

SKU: orb1226838

Description

JNJ-42041935 is a potent, selective, 2-OG-competitive, reversible inhibitor of HIF-PHD with pKi of 7.91, 7.29 and 7.65 for PHD1, PHD2 and PHD3, respectively; shows highly selectivity for PHD relative to FIH (pIC50=4.0); JNJ-42041935 is approximately equipotent in the HIF-1α accumulation and erythropoietin secretion assays in Hep3B cells as DMOG and 3,4-EDHB; reverses inflammation-induced anemia at dose of 100 μmol/kg, whereas erythropoietin has no effect.

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Key Properties

CAS Number1193383-09-3
MW346.6493
Purity>98% (HPLC)
FormulaC12H6ClF3N4O3
SMILESClC1=CC2=C(NC(N3C=C(C(O)=O)C=N3)=N2)C=C1OC(F)(F)F
TargetHIF/HIF Prolyl-hydroxylase
SolubilityDMSO: ≥ 36 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

JNJ42041935

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  • JNJ-42041935 [orb1304454]

    >99.99% (May vary between batches)

    1193383-09-3

    346.65

    C12H6ClF3N4O3

    2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 mg, 500 mg, 1 ml x 10 mM (in DMSO)
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JNJ-42041935 (orb1226838)

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Available Sizes

Select a size below

2 mg
$ 90.00
5 mg
$ 140.00
10 mg
$ 190.00
25 mg
$ 320.00
50 mg
$ 510.00
100 mg
$ 790.00
500 mg
$ 1,640.00