JNJ-38158471

SKU: orb1305986

Description

JNJ-38158471 (CS-2660) is a potent and selective oral VEGFR2 inhibitor (IC50=40 nM) with additional activity against Ret and Kit kinases. This compound is suitable for in vitro biochemical assays and in vivo research models investigating angiogenesis and oncogenic kinase signaling pathways.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 951151-97-6
• MW: 364.79
• Purity: 98.04% (May vary between batches)
• Formula: C₁₅H₁₇ClN₆O₃
• SMILES: CCNC(=O)Nc1ccc(Oc2ncnc(N)c2\C=N\OC)cc1Cl
• Target: c-RET,c-Kit,VEGFR
• Solubility: 10% DMSO+90% Corn Oil:2 mg/mL (5.48 mM);DMSO:30 mg/mL (82.24 mM)

Bioactivity

• Target IC50:
  c-Kit:500 nM|RET:180 nM|VEGFR2:40 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

malignancies, Inhibitor, inhibit, Kit, JNJ38158471, JNJ-38158471, JNJ 38158471, cancer, CD117, c-Kit, cKit, CS2660, CS-2660, CS 2660, cRET, VEGFR, VEGFR-2, VEGFR2, Vascular endothelial growth factor receptor, SCFR, RET, Ret

Compound Identifiers

PubChem CID

16742063