JNJ-1289

SKU: orb1689291

Description

JNJ-1289 is a potent and selective competitive inhibitor of human spermine oxidase (hSMOX; IC50 = 50 nM). This small molecule is a valuable research tool for investigating polyamine catabolism in the contexts of cancer and inflammation, supporting both in vitro and in vivo experimental studies.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 792898-18-1
• MW: 308.36
• Purity: 98.16% (May vary between batches)
• Formula: C₁₆H₁₂N₄OS
• SMILES: N(C1=NC(C=2N3C(=NC2)C=CC=C3)=CS1)C4=CC=C(O)C=C4
• Target: Smo,Others
• Solubility: DMSO:50 mg/mL (162.15 mM);10% DMSO+90% Saline:2.5 mg/mL (8.11 mM)

Bioactivity

• In Vitro:
  In a time-dependent manner, JNJ-1289 inhibits hSMOX activity, with assessments at 0 and 2 hours. Initially, JNJ-1289 forms a weak complex with hSMOX, characterized by an apparent Ki value of 1.4 μM. Subsequently, a relatively slow protein isomerization occurs, leading to the formation of the final tightly bound inhibitor-enzyme complex.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

hSmo

Compound Identifiers

PubChem CID

164513391