JMX0293

• Catalog Number: orb1744186
• Category: Small Molecules
• Description: JMX0293, an O-alkylamino-tethered salicylamide derivative, demonstrates strong efficacy against the TNBC MDA-MB-231 cell line with an IC50 of 3.38 μM, while showing minimal toxicity towards the non-tumorigenic human breast epithelial cell line MCF-10A, where its IC50 exceeds 60 μM. It inhibits STAT3 phosphorylation, contributing to apoptosis in MDA-MB-231 cells, and significantly suppresses MDA-MB-231 xenograft tumor growth in vivo, all without notable toxicity.
• Purity: 98.00%
• MW: 569.43
• SMILES: CC(OC(NCCOC1=C(C=C(C=C1)Cl)C(N[C@@H](C(C)C)C(NC2=C(C=C(C=C2)[N+]([O-])=O)Cl)=O)=O)=O)(C)C
• Formula: C₂₅H₃₀Cl₂N₄O₇
• Biological Activity: JMX0293, an O-alkylamino-tethered salicylamide derivative, demonstrates strong efficacy against the TNBC MDA-MB-231 cell line with an IC50 of 3.38 μM, while showing minimal toxicity towards the non-tumorigenic human breast epithelial cell line MCF-10A, where its IC50 exceeds 60 μM. It inhibits STAT3 phosphorylation, contributing to apoptosis in MDA-MB-231 cells, and significantly suppresses MDA-MB-231 xenograft tumor growth in vivo, all without notable toxicity.
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.