JMJD3/HDAC-IN-1

SKU: orb1944184

Description

JMJD3/HDAC-IN-1 (A5b) is a dual inhibitor of JMJD3 and HDAC1 (IC50 = 16 nM). It modulates histone marks by inducing H3K27 hypermethylation and H3K9 hyperacetylation, promoting apoptosis via caspase-7/PARP cleavage. This compound is used in cancer research to study epigenetic mechanisms and has shown efficacy in inhibiting cell proliferation, migration, and invasion in vitro.

Research Area

Cell Biology, Epigenetics & Chromatin, Metabolism Research; Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 2883046-06-6
• MW: 398.5
• Formula: C₂₁H₃₀N₆O₂
• SMILES: N(CCCCCC(NO)=O)C=1N=C(N=C(C1)N2CCCCCC2)C3=CC=CC=N3
• Target: HDAC

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

168679855