JLK6

SKU: orb1306163

Description

JLK6 is a gamma-secretase inhibitor noted for its selectivity, as it does not disrupt Notch signaling pathways. This compound is utilized in Alzheimer's disease research and other amyloid-related studies, enabling in vitro and in vivo investigations of gamma-secretase function independent of Notch effects.

Research Area

Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 62252-26-0
• MW: 225.63
• Purity: 96.50% (May vary between batches)
• Formula: C₁₀H₈ClNO₃
• SMILES: ClC=1C=2C(C(=O)OC1OC)=CC(N)=CC2
• Target: Beta Amyloid,Gamma-secretase
• Solubility: DMSO:22 mg/mL (97.5 mM);Ethanol:5 mg/mL (22.16 mM)

Bioactivity

• Target IC50:
  γ-secretase:10 μM-1 mM
• In Vitro:
  JLK6 markedly reduced Aβ secreted from HEK293 cells. Immunological characterization indicated that one fragment was labelled with a specific antibody against the Asp1 residue of Aβ.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Abeta, APP, Amyloid-β, amyloid β, JLK 6, JLK6, JLK-6, inhibit, Inhibitor, Gammasecretase, β-amyloid peptide, γ-secretase

Compound Identifiers

PubChem CID

3803