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JKE-1716

SKU: orb3177649

Description

JKE-1716 is an inhibitor of glutathione peroxidase 4 (GPX4) and a derivative of the GPX4 inhibitor ML-210 .1JKE-1716 reduces viability of LOX-IMVI cancer cells in a concentration-dependent manner and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 .

Research Area

Cell Biology, Metabolism Research

Images & Validation

Key Properties

CAS Number2421118-05-8
MW451.3
FormulaC20H20Cl2N4O4
SMILESO\N=C(\CC(=O)N1CCN(CC1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)[N+]([O-])=O
TargetOthers,Glutathione Peroxidase,Ferroptosis

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information