JKE-1716

SKU: orb3177649

Description

JKE-1716 is an inhibitor of glutathione peroxidase 4 (GPX4) and a derivative of the GPX4 inhibitor ML-210 .1JKE-1716 reduces viability of LOX-IMVI cancer cells in a concentration-dependent manner and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 .

Key Properties

• CAS Number: 2421118-05-8
• MW: 451.3
• Formula: C₂₀H₂₀Cl₂N₄O₄
• SMILES: O\N=C(\CC(=O)N1CCN(CC1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)[N+]([O-])=O
• Target: Ferroptosis,Glutathione Peroxidase,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Ferroptosis,Glutathione Peroxidase,Others