JI6

SKU: orb1819235

Description

JI6 (JAK3 Inhibitor VI) is a potent, selective and orally active FLT3 inhibitor. JI6 exhibits IC50s of ∼40, 8, and 4 nM for FLT3-WT, FLT3-D835Y, and FLT3-D835H, respectively. JI6 also inhibits c-Kit and JAK3, with IC50s of ∼500 and ∼250 nM, respectively. JI6 has research value in acute myeloid leukemia.

Key Properties

• CAS Number: 856436-16-3
• MW: 383.42
• Purity: 97.74%
• Formula: C₁₉H₁₇N₃O₄S
• SMILES: CS(=O)(O)=O.O=C(/C1=C\C2=CC=CN2)NC(C=C3)=C1C=C3C4=CN=CC=C4
• Target: JAK,FLT,c-Kit

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

JAK,FLT,c-Kit