JI130

SKU: orb1298001

Description

JI130 is a small molecule inhibitor that disrupts the transcriptional repressor function of Hes1. This mechanism has demonstrated efficacy in reducing tumor growth in a pancreatic cancer xenograft model, supporting its use in oncology research for studying Notch signaling pathways both in vitro and in vivo.

Research Area

Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2234271-86-2
• MW: 376.45
• Purity: 99.61% (May vary between batches)
• Formula: C₂₃H₂₄N₂O₃
• SMILES: C(=C/C(NCCC1=C(OCC=C)C=CC=C1)=O)\C=2C=3C(=C(OC)C=CC3)NC2
• Target: Gamma-secretase,Others
• Solubility: DMSO:70 mg/mL (185.95 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Hes1, JI 130, JI130, JI-130

Compound Identifiers

PubChem CID

154730572