JI051

SKU: orb1709367

Description

JI051 is a small molecule antitumor agent that targets the chaperone protein prohibitin 2 (PHB2). Its mechanism involves suppressing Hes1 transcription, a key Notch pathway effector, leading to cell cycle arrest and inhibition of proliferation in HEK293 and pancreatic cancer cell lines in vitro.

Research Area

Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2234281-75-3
• MW: 364.44
• Purity: ≥98% (May vary between batches)
• Formula: C₂₂H₂₄N₂O₃
• SMILES: CCOc1ccccc1CCNC(=O)\C=C\c1c[nH]c2c(OC)cccc12
• Target: Gamma-secretase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.98 mM);DMSO:100 mg/mL (274.39 mM)

Bioactivity

• Target IC50:
  Cell proliferation:0.3 μM (EC50, HEK293 cell)
• In Vitro:
  JI051 (0.1-10 µM, 24 hours) significantly inhibits proliferation of HEK293 cells, exhibiting an EC50 of 0.3 μM, and induces G2/M cell-cycle arrest.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Gammasecretase, Notch, JI 051, JI051, JI-051

Compound Identifiers

PubChem CID

138319697