JHU37152

SKU: orb1298441

Description

JHU37152 is a potent and selective DREADD agonist, exhibiting high affinity and efficacy at engineered hM3Dq and hM4Di receptors. It is a key research tool for precise chemogenetic manipulation of neuronal activity in both in vitro cellular assays and in vivo models for neuroscience and behavioral studies.

Research Area

Neuroscience

Key Properties

• CAS Number: 2369979-67-7
• MW: 358.84
• Purity: 99.72% (May vary between batches)
• Formula: C₁₉H₂₀ClFN₄
• SMILES: CCN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2cccc(F)c12
• Target: AChR
• Solubility: Ethanol:24 mg/mL (66.88 mM);DMSO:72 mg/mL (200.65 mM)

Bioactivity

• Target IC50:
  M3Dq DREADD (human):5 nM (EC50)|M4Di DREADD (human):0.5 nM (EC50)
• In Vivo:
  JHU 37152 exhibits high in vivo DREADD potency. JHU37152 exhibits selective [3H]clozapine displacement from DREADDs in brain tissue from WT and D1-DREADD mice
• In Vitro:
  JHU 37152 is a potent DREADD agonist with high potency and efficacy in fluorescent and BRET-based assays in HEK-293 cells, whereas no responses are observed in untransfected HEK-293 cells

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Muscarinic acetylcholine receptor, JHU 37152, JHU37152, JHU-37152, M3 mAChR, mAChR, hM4Di, hM3Dq, Inhibitor, DREADD, Clozapine

Compound Identifiers

PubChem CID

139033721