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JH295 hydrate

SKU: orb1688975

Description

JH295 hydrate is a potent, selective, and irreversible Nek2 inhibitor that acts via alkylation of Cys22 (IC50 = 770 nM). It exhibits high selectivity, showing no activity against Cdk1, Aurora B, or Plk1, and does not disrupt spindle assembly or checkpoint function, making it a valuable chemical probe for studying Nek2's role in cancer and cell cycle research.

Research Area

Signal Transduction

Images & Validation

Key Properties

MW338.36
FormulaC18H18N4O3
TargetMAPK,Others

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information