JH-XI-10-02

SKU: orb1707920

Description

JH-XI-10-02 is a potent and selective PROTAC that induces proteasomal degradation of CDK8 with an IC50 of 159 nM, without affecting CDK19 or CDK8 mRNA levels. This degrader is a valuable chemical probe for studying CDK8's role in transcription and disease models in both cellular and biochemical assays.

Research Area

Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2209085-22-1
• MW: 920.161
• Formula: C₅₃H₆₉N₅O₉
• SMILES: [H][C@@]1(CC[C@@]2([H])[C@]3([H])CC[C@@]4([H])C[C@H](CC[C@]4(C)[C@@]3([H])CC[C@]12C)N(C)C(=O)CCOCCOCCOCCOCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12)c1ccc2ccncc2c1
• Target: PROTACs,CDK,EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

145708490