JH-IX-179

SKU: orb1985924

Description

JH-IX-179 is a potent and highly selective type I ATP-competitive inhibitor of FLT3, including D835Y and ITD mutants. It demonstrates minimal serum protein binding and effectively blocks FLT3 autophosphorylation and downstream signaling. This profile supports its utility in preclinical research for investigating FLT3-driven pathologies, such as acute myeloid leukemia, in both cellular and animal models.

Key Properties

• MW: 436.52
• Formula: C₂₆H₂₄N₆O
• SMILES: O=C1C2=C(NC3=C2C=CC(C4=CNN=C4)=C3)C5=C1C=CC(C6=CN(CCCN(C)C)N=C6)=C5
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

127052113