JH-II-127

SKU: orb1300021

Description

JH-II-127 is a potent, orally bioavailable small molecule inhibitor of LRRK2, demonstrating nanomolar IC50 values against wild-type (6.6 nM), G2019S (2.2 nM), and A2016T (47.7 nM) variants. This compound is a valuable research tool for investigating LRRK2 biology and its implications in Parkinson's disease through in vitro and in vivo models.

Research Area

Cell Biology

Key Properties

• CAS Number: 1700693-08-8
• MW: 416.86
• Purity: ≥98%
• Formula: C₁₉H₂₁ClN₆O₃
• SMILES: CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2)nc2[nH]cc(Cl)c12
• Target: LRRK2
• Solubility: DMSO:30 mg/mL (71.97 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.8 mM)

Bioactivity

• Target IC50:
  LRRK2 (G2019S):2.2 nM |LRRK2 (WT):6.6 nM |LRRK2 (A2016T):47.7 nM
• In Vivo:
  JH-II-127 (0.1-0.3 μM) inhibits phosphorylation of the serines at positions 910 and 935 of WT LRRK2 and LRRK2G2019S in vitro. It also inhibits Ser935 phosphorylation in vivo in mouse brain, spleen, and kidney when administered at a dose of 30 mg/kg.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ser935, 3T3 cells, parkinson's disease, LRRK2-A2016T, LRRK2-G2019S, LRRK2, Inhibitor, inhibit, JHII127, JH-II127, JH-II-127, JH-II 127, JH II 127, Leucine-rich repeat kinase 2, HEK293

Compound Identifiers

PubChem CID

112499966