JC2-11

SKU: orb1819061

Description

JC2-11 is a small molecule inhibitor that suppresses inflammasome activation by targeting NLRC4 and AIM2 pathways. It disrupts ROS production and caspase-1 activity, thereby reducing GSDMD cleavage, IL-1β maturation, and LDH release. This compound is a valuable research tool for studying pyroptosis and inflammation in both cellular and animal models of inflammatory diseases.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Protein Biochemistry

Key Properties

• CAS Number: 937820-89-8
• MW: 302.3
• Purity: 99.88%
• Formula: C₁₇H₁₅FO₄
• SMILES: C(/C=C/C1=CC(OC)=C(O)C=C1)(=O)C2=CC(F)=C(OC)C=C2
• Target: IL Receptor,AIM2,NOD-like Receptor (NLR),Caspase,Dehydrogenase,ROS
• Solubility: DMSO:127.5 mg/mL (421.77 mM)

Bioactivity

• In Vivo:
  JC2-11 (250 μg/mouse; i.p.; single dose) significantly inhibited the release of caspase-1 (p20) and IL-1β from the non-canonical (NC) inflammasome in the C57BL/6 mouse model, attenuated NC inflammasome activation.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LDH, NODlikeReceptor(NLR), NODlikeReceptor, NOD-like Receptor (NLR), NOD-like Receptor, NODlike Receptor (NLR), NLR, JC211, JC2-11, IL Receptor, IL-1β, ILReceptor, Caspase-1, AIM2, ROS

Compound Identifiers

PubChem CID

24895134