JC124

SKU: orb1702158

Description

JC124 is a selective small molecule inhibitor of the NLRP3 inflammasome. It demonstrates neuroprotective and anti-inflammatory effects, making it a valuable research tool for studying NLRP3-driven pathologies in models of neurodegenerative and inflammatory diseases both in vitro and in vivo.

Research Area

Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 1638611-48-9
• MW: 382.86
• Purity: 99.64% (May vary between batches)
• Formula: C₁₇H₁₉ClN₂O₄S
• SMILES: CNS(=O)(=O)c1ccc(CCNC(=O)c2cc(Cl)ccc2OC)cc1
• Target: NOD,NOD-like Receptor (NLR)
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (13.06 mM);DMSO:225 mg/mL (587.68 mM)

Bioactivity

• In Vivo:
  In adult male Sprague-Dawley rats bearing traumatic brain injury, intraperitoneal administration of JC124 (100 mg/kg) reduces the number of injury-induced degenerating neurons, inflammatory cell response, and cortical lesion volume. JC124 decreases the expression of NLRP3, IL-1 beta, TNFα, ASC, iNOS, and caspase-1.
• In Vitro:
  JC124 selectively inhibits NLRP3 inflammasome formation and activates caspase-1, and reduces IL-1β.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

JC124, JC-124, JC 124, NLRP3

Compound Identifiers

PubChem CID

117715670