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JBJ-02-112-05

SKU: orb1709370

Description

JBJ-02-112-05 is an orally bioavailable, allosteric inhibitor that selectively targets mutant EGFR, specifically the L858R/T790M variant, with high potency (IC50 = 15 nM). It is a valuable research tool for investigating resistance mechanisms in non-small cell lung cancer (NSCLC) in both cellular and animal models.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number2748162-29-8
MW464.54
FormulaC27H20N4O2S
SMILESC(C(NC1=NC=CS1)=O)(N2C(=O)C=3C(C2)=CC=C(C3)C=4C=C5C(=CC4)NC=C5)C6=CC=CC=C6
TargetJAK,EGFR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

JBJ-02-112-05 (orb1709370)

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