JB062

SKU: orb1741323

Description

JB062 is a selective nonmuscle myosin inhibitor with IC50 values of 1.6 μM (skeletal), 5.4 μM (cardiac), and >100 μM (smooth muscle). It demonstrates selective cytotoxicity against human cancer cells in vitro and is a research tool for studying muscle spasticity, chronic pain, and hypertrophic cardiomyopathy.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2417988-00-0
• MW: 323.34
• Purity: 99.89% (May vary between batches)
• Formula: C₁₉H₁₇NO₄
• SMILES: OC=1C=2C(OC(=O)C1C(=NCC3=CC=C(OC)C=C3)C)=CC=CC2
• Target: Myosin
• Solubility: DMSO:22.5 mg/mL (69.59 mM)

Bioactivity

• Target IC50:
  Cardiac muscle myosin:5.4 μM|Skeletal muscle myosin:1.6 μM|Smooth muscle myosin II:>100 μM
• In Vitro:
  JB062 (40 μM ; 24 h) inhibited cytoplasmic division in COS-7 cells. JB062 (COS-7 cells) exhibited cytotoxicity against human cancer cells but showed no cytotoxicity towards normal cells, with an IC50 value of 36 μM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Myosin

Compound Identifiers

PubChem CID

146020961