Jarin-1

SKU: orb1707164

Description

Jarin-1 is a potent and specific inhibitor of jasmonic acid-amido synthetase (JAR1) with an IC50 of 3.8 µM. It effectively suppresses bioactive jasmonate biosynthesis and is a valuable chemical tool for studying JA signaling in plant defense, development, and stress responses using both in vitro enzymatic assays and in vivo plant models like Arabidopsis.

Key Properties

• CAS Number: 1212704-51-2
• MW: 471.55
• Purity: 99.82% (May vary between batches)
• Formula: C₂₈H₂₉N₃O₄
• SMILES: [H][C@@]12CN(C[C@@]([H])(C1)c1ccc(NC(=O)c3ccc(cc3)-c3ccccc3)c(=O)n1C2)C(=O)CCOC
• Target: Others
• Solubility: DMSO:150 mg/mL (318.1 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.24 mM)

Bioactivity

• In Vitro:
  MeJA + Jarin-1 treatment caused an upregulation of FaANR and associated transcription factors such as FabHLH33 and FaMYB9/11 along with FaJMT and FaJAR1.2. JA-responsive elements in the promoter regions of FaMYB1/9/10/11 genes are found. The proanthocyanidin (PA) content was higher in Jarin-1- and MeJA + Jarin-1-treated than in MeJA-treated fruits. PA biosynthesis-related genes can be upregulated by the application of Jarin-1 to MeJA-treated fruit, thus increasing PA accumulation in strawberry. A higher redness of strawberry fruit skin and anthocyanin content in MeJA-treated fruits with respect to Jarin-1-treated ones concomitant with an upregulation of FaANS and FaUFGT genes is found .

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Jasmonic acid-amido synthetase (JAR1), Jarin 1, Jarin1, Jarin-1

Compound Identifiers

PubChem CID

7142742