JAK/HDAC-IN-4

SKU: orb2695318

Description

JAK/HDAC-IN-4 (compound 11i) is a potent dual JAK2/HDAC6 inhibitor with IC50 values of 0.49 nM and 12 nM, respectively. It demonstrates anti-proliferative activity, suppresses nitric oxide production in vitro, and effectively reduces psoriasiform lesions in an imiquimod-induced mouse model with a favorable toxicity profile.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Molecular Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• MW: 616.69
• Formula: C₃₀H₃₂N₈O₅S
• SMILES: C(/C=C/C1=CC=C(I)C=C1)(=O)C2=CC=C(B(O)O)C=C2
• Target: HDAC|||JAK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

10022508