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JAK/HDAC-IN-4

SKU: orb2695318

Description

JAK/HDAC-IN-4 (compound 11 i) is a dual inhibitor targeting both JAK2 and HDAC6, with IC50 values of 0.49 nM and 12 nM respectively. It inhibits cell proliferation and the production of nitric oxide. In a mouse model induced by Imiquimod, JAK/HDAC-IN-4 ameliorates psoriasiform skin lesions with low toxicity.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Molecular Biology, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

MW616.69
FormulaC30H32N8O5S
TargetJAK,HDAC

Storage & Handling

Storage-20°C
DisclaimerFor research use only
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Protocol Information

JAK/HDAC-IN-4 (orb2695318)

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