JAK3 covalent inhibitor-1

SKU: orb1709373

Description

JAK3 Covalent Inhibitor-1 is a potent and selective small molecule inhibitor of Janus kinase 3 (JAK3) with an IC50 of 11 nM, showing 246-fold selectivity over other JAK family members. This compound is a valuable research tool for investigating JAK3-dependent signaling in immunological and inflammatory disease models, both in vitro and in vivo.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2300106-50-5
• MW: 448.47
• Formula: C₂₂H₁₇FN₆O₂S
• SMILES: N(C#N)[C@@H]1C=2C([C@H](NS(=O)(=O)C3=CC(F)=CC=C3)C1)=CC=C(C2)C4=C5C(=NC=N4)NC=C5
• Target: JAK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

137321159