JAK2-IN-20

SKU: orb3210212

Description

JAK2-IN-20 is an orally active dual inhibitor targeting JAK2 kinase (IC50=49.17 nM) and influenza A virus PB2 protein (IC50=3.337 μM, Kd=2.82 μM). It effectively blocks the JAK/STAT signaling pathway by reducing phosphorylation levels of STAT1 and STAT3, thereby inhibiting viral replication and downregulating the expression of viral NP and PB2 proteins. Additionally, JAK2-IN-20 significantly suppresses the mRNA expression of key inflammatory factors such as IL-6, TNF-α, and IFN-β in models of inflammation and influenza infection. This compound serves as an important molecular tool for research into influenza A virus infections and related pathologies.

Key Properties

• Target: JAK,Influenza Virus

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

JAK,Influenza Virus