JAK2-IN-18

SKU: orb3174427

Description

JAK2-IN-18 (Compound example1) is a selective JAK2 inhibitor. It effectively inhibits the JAK-STAT signaling pathway, with an IC50 value of less than 100 nM for pSTAT5 in HEL9217 cells. JAK2-IN-18 suppresses the proliferation of abnormally proliferating myeloid cells and is useful in research on myeloproliferative disorders, such as essential thrombocythemia.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 3108318-77-7
• MW: 656.75
• Formula: C₃₇H₃₆N₈O₄
• SMILES: O=C(C=1N=C(C=CC1)CN2C(=O)C3=CC=C(C=C3C4(C2)CC4)C=5C=CC=C(NC6=CC(=NN7C=CN=C67)NC(=O)C8CC8)C5OC)N(C)C
• Target: STAT,JAK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

STAT,JAK