JAK1-IN-20

SKU: orb3210949

Description

JAK1-IN-20 (Compound 38) is a gut-restricted, orally active, selective JAK1 inhibitor with an IC50 of less than 0.5 nM. It inhibits the enzymatic activity of JAK1, reduces the production of pro-inflammatory cytokines (TNF-α, IL-6), and suppresses the phosphorylation of STAT3. JAK1-IN-20 shows potential in improving ulcerative colitis and is used in inflammatory bowel disease research.

Key Properties

• CAS Number: 3106963-85-0
• MW: 537.97
• Formula: C₂₆H₂₅ClFN₇O₃
• SMILES: O=C1NCC2=CC(=CC=C12)NC3=NC=C(Cl)C(=N3)NC4CCN(C(=O)NC5=CC=C(C=C5F)C(=O)C)CC4
• Target: Interleukin,JAK,STAT

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Interleukin,JAK,STAT