JAK05

SKU: orb2945400

Description

JAK05 exhibits inhibitory activity against Helicobacter pylori, effectively suppressing strains J63, J196, and J107, with a MIC of 3-5 µg/mL. It shows affinity for binding to H+/K+-ATPase, COX-1/2, TNF-α, and PGE2, and possesses antioxidant and anti-inflammatory properties. In a rat model of ethanol-induced gastric ulcers, JAK05 demonstrates anti-ulcer activity.

Key Properties

• MW: 619.043
• Formula: C₂₇H₂₇ClN₄O₉S
• SMILES: CC(=O)OC[C@H]1[C@@H]([C@@H]([C@@H]([C@H](O1)N2C(=S)N(C(=N2)C3=CC=NC=C3)C4=CC=C(C=C4)Cl)OC(=O)C)OC(=O)C)OC(=O)C
• Target: TNF,Prostaglandin Receptor,Antibacterial,ATPase,COX

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

TNF,Prostaglandin Receptor,Antibacterial,ATPase,COX