JAK-IN-14

SKU: orb1685227

Description

JAK-IN-14 (compound 16) is a potent and selective JAK1 inhibitor (IC50 <5 μM) with over 8-fold selectivity against JAK2/JAK3. It functions by binding the JAK1 active site to inhibit its phosphorylation. This inhibitor is a valuable research tool for studying immune, inflammatory, and oncological pathways in both cellular and animal models.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1973485-06-1
• MW: 334.35
• Purity: 98.27% (May vary between batches)
• Formula: C₁₉H₁₅FN₄O
• SMILES: N#CCC=1C=CC(=C(F)C1)C2=CC=CC3=NC(=CN32)NC(=O)C4CC4
• Target: JAK
• Solubility: DMSO:5 mg/mL (14.95 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.99 mM)

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

JAK IN 14, JAK-IN-14, JAKIN14

Compound Identifiers

PubChem CID

122462783