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J30-8

SKU: orb2901812

Description

J30-8 is a potent and isoform-selective inhibitor of c-Jun N-terminal kinase 3 (JNK3) with an IC50 of 40 nM, which 2500-fold isoform selectivity against JNK1α1 and JNK2α2. J30-8 exhibits neuroprotective activity in vitro and potential for the treatment of neurodegenerative diseases.

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Key Properties

CAS Number2366255-71-0
MW373.79
Purity>98% (HPLC)
FormulaC17H9ClFN3O2S
SMILESFc1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N/c3ccccc3Cl)c2c1
TargetJNK
SolubilityIn Vitro: DMSO : 6.67 mg/mL (17.84 mM; Ultrasonic (<60°C)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information

J30-8 (orb2901812)

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