J14

SKU: orb1299039

Description

J-14 is a small molecule inhibitor of sulfiredoxin with an IC50 of 8.1 µM. By blocking this antioxidant enzyme, J-14 elevates intracellular reactive oxygen species (ROS), inducing oxidative stress-mediated cytotoxicity in cancer cells, making it a useful research tool for studying redox biology in vitro.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 1043854-13-2
• MW: 517.04
• Purity: 99.51% (May vary between batches)
• Formula: C₂₈H₂₅ClN₄O₂S
• SMILES: OC(=O)c1ccc(CSc2nc(cc(n2)-c2ccccc2)N2CCN(CC2)c2ccccc2Cl)cc1
• Target: Reactive Oxygen Species,ROS
• Solubility: DMSO:260 mg/mL (502.86 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (9.67 mM)

Bioactivity

• Target IC50:
  Sulfiredoxin:8.1 μM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Sulfiredoxin, sulfiredoxin, ReactiveOxygenSpecies, Reactive Oxygen Species, cancer, adenocarcinoma, cells, cytotoxicity, damage, Inhibitor, death, mitochondrial, lung, J14, J-14, J 14, inhibit

Compound Identifiers

PubChem CID

45987688