Ixazomib Citrate

SKU: orb1226812

Description

MLN9708 immediately hydrolyzed to MLN2238, the biologically active form, on exposure to aqueous solutions or plasma. MLN2238 inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50/Ki of 3.4 nM/0.93 nM, less potent to β1 and little activity to β2. Phase 3.

Key Properties

• CAS Number: 1201902-80-8
• MW: 517.12
• Purity: >98% (HPLC)
• Formula: C₂₀H₂₃BCl₂N₂O₉
• SMILES: B1(OC(=O)CC(O1)(CC(=O)O)C(=O)O)[C@H](CC(C)C)NC(=O)CNC(=O)C2=C(C=CC(=C2)Cl)Cl
• Target: Proteasome
• Solubility: DMSO: 100 mg/mL (193.37 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ixazomib Citrate

Quick Database Links

Gene Symbol

Proteasome