IXA6

SKU: orb1687476

Description

IXA6 is a novel small molecule agonist that selectively activates the IRE1-XBP1 signaling pathway, inducing the XBP1s transcriptional response. It serves as a research tool for investigating endoplasmic reticulum stress in models of neurodegenerative diseases, including Parkinson's and Alzheimer's disease, in both cellular and animal studies.

Research Area

Cell Biology

Key Properties

• CAS Number: 1021106-40-0
• MW: 441.93
• Purity: 98.63%
• Formula: C₂₂H₂₀ClN₃O₃S
• SMILES: ClC1=CC=C(CN(CC(=O)N2CCC3=C2C=CC=C3)S(=O)(=O)C2=CC=CN=C2)C=C1
• Target: IRE1

Bioactivity

• In Vitro:
  IXA6 ( 10μM ; 4 or 18h ) selectively activates IRE1-XBP1s signaling, activates IRE1 to reduce APP secretion, and selectively reshapes IRE1-XBP1s-dependent ER protein homeostasis.

Storage & Handling

• Storage: store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

IRE1/XBP1s

Compound Identifiers

PubChem CID

42111339