IWR-1 endo

SKU: orb1305217

Description

IWR-1-endo is a potent small molecule inhibitor of the Wnt signaling pathway with an EC50 of 0.2 µM, functioning by stabilizing the Axin destruction complex. It is widely used in biochemical and cellular research, including studies of stem cell differentiation and cancer biology, both in vitro and in vivo.

Research Area

Cancer Biology, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1127442-82-3
• MW: 409.4
• Purity: >98%
• Formula: C₂₅H₁₉N₃O₂
• SMILES: O=C(Nc1cccc2cccnc12)c1ccc(cc1)N1C(=O)C2C3CC(C=C3)C2C1=O
• Target: Cytoskeleton
• Solubility: Soluble in DMSO (up to at least 10 mg/ml)

Bioactivity

• Target IC50:
  Wnt:0.2 μM (EC50)|HEK293T cells:26 nM|SW48 cells:2.5 μM (EC50)|HT29 cells:24.4 μM|SW48 cells:0.25 μM
• In Vivo:
  In the Wnt pathway, IWR-1 interacts with Axin to exert a reversible inhibitory effect.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

bcatenin, beta-catenin, betacatenin, inhibit, IWR 1, IWR1, IWR-1, IWR-1-endo, Inhibitor, endo-IWR 1, βcatenin, Wnt/β-catenin, Wnt, Wnt/betacatenin, Wnt/b-catenin

Compound Identifiers

PubChem CID

3137736