IWP L6

SKU: orb1305171

Description

IWP L6 (Porcn Inhibitor III) is a potent small molecule inhibitor of Porcn with an EC50 of 0.5 nM. It is widely used in biochemical and cellular assays to study Wnt signaling and has been applied in both in vitro and in vivo models to investigate development and disease mechanisms.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1427782-89-5
• MW: 472.58
• Purity: >99.99% (May vary between batches)
• Formula: C₂₅H₂₀N₄O₂S₂
• SMILES: O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cn1)-c1ccccc1
• Target: Porcupine
• Solubility: DMSO:4.73 mg/mL (10.01 mM)

Bioactivity

• Target IC50:
  Porcn:0.5 nM(EC50)
• In Vivo:
  In cultured embryonic kidneys, IWP-L6 can reversibly block the Wnt signaling pathway, thereby inhibiting Wnt-mediated branching morphogenesis. It also impedes the phosphorylation of Dvl2, a cytoplasmic effector of the Wnt pathway, in HEK293 cells.
• In Vitro:
  In zebrafish embryos, IWP-L6 significantly inhibits the formation of posterior vertebrae, which is dependent on Wnt/β-catenin. IWP-L6 exhibits stability in human plasma (>24 hours) but shows rapid metabolism in rat plasma (half-life: 190 minutes), mouse plasma (half-life: 2 minutes), and mouse liver S9 fractions.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, IWP L 6, IWP L6, IWP L-6, IWP-L6, Porcn, Porcn Inhibitor III, Porcn Inhibitor III, Porcn?Inhibitor?III, Porcupine

Compound Identifiers

PubChem CID

71601111