IWP L6

SKU: orb1305171

Description

IWP L6

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1427782-89-5
• MW: 472.58
• Purity: >99.99%
• Formula: C₂₅H₂₀N₄O₂S₂
• SMILES: O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cn1)-c1ccccc1
• Target: Porcupine
• Solubility: DMSO:4.73 mg/mL (10.01 mM)

Bioactivity

• Target IC50:
  Porcn:0.5 nM(EC50)
• In Vivo:
  In cultured embryonic kidneys, IWP-L6 can reversibly block the Wnt signaling pathway, thereby inhibiting Wnt-mediated branching morphogenesis. It also impedes the phosphorylation of Dvl2, a cytoplasmic effector of the Wnt pathway, in HEK293 cells.
• In Vitro:
  In zebrafish embryos, IWP-L6 significantly inhibits the formation of posterior vertebrae, which is dependent on Wnt/β-catenin. IWP-L6 exhibits stability in human plasma (>24 hours) but shows rapid metabolism in rat plasma (half-life: 190 minutes), mouse plasma (half-life: 2 minutes), and mouse liver S9 fractions.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, IWP L 6, IWP L6, IWP L-6, IWP-L6, Porcn, Porcn Inhibitor III, Porcn Inhibitor III, Porcn?Inhibitor?III, Porcupine

Compound Identifiers

PubChem CID

71601111