IWP-3

SKU: orb1705001

Description

IWP-3 is a potent small molecule Wnt inhibitor that blocks Wnt protein palmitoylation, suppressing oncogenic signaling. It reduces viability in cancer cell lines like MG63 and is applied in myeloma and other cancer research, supporting both in vitro and in vivo studies of Wnt pathway dysregulation.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 687561-60-0
• MW: 484.589
• Purity: 98.54% (May vary between batches)
• Formula: C₂₂H₁₇FN₄O₂S₃
• SMILES: CC1=CC2=C(C=C1)N=C(NC(=O)CSC1=NC3=C(SCC3)C(=O)N1C1=CC=C(F)C=C1)S2
• Target: Wnt/beta-catenin
• Solubility: DMSO:15 mg/mL (30.95 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

beta-catenin, betacatenin, bcatenin, IWP3, IWP-3, IWP 3, βcatenin, Wnt/β-catenin, Wnt/betacatenin, Wnt/b-catenin, Wnt

Compound Identifiers

PubChem CID

2155389