IWP 12

SKU: orb1704455

Description

IWP-12 is a potent and selective small-molecule inhibitor of Porcupine (Porcn), a key enzyme in Wnt ligand secretion. By blocking the Wnt signaling pathway, it is a valuable tool for studying Wnt-dependent processes, including tissue regeneration, as demonstrated by its inhibition of fin regrowth in zebrafish models.

Research Area

Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 688353-45-9
• MW: 418.556
• Purity: 99.75% (May vary between batches)
• Formula: C₁₈H₁₈N₄O₂S₃
• SMILES: CC1CC2=C(S1)C(=O)N(C)C(SCC(=O)NC1=NC3=C(S1)C=C(C)C=C3)=N2
• Target: Wnt/beta-catenin,Acyltransferase,Porcupine
• Solubility: DMSO:20 mg/mL (47.78 mM)

Bioactivity

• Target IC50:
  Porcupine:15 nM
• In Vitro:
  IWP 12 is a potent porcupine (PORCN) inhibitor that blocks cell-autonomous Wnt signaling with an IC50 of 15 nM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

IWP12, IWP-12, IWP 12

Compound Identifiers

PubChem CID

3244448