iVeliparib-AP6

SKU: orb3210454

Description

iVeliparib-AP6 is a Veliparib-based PROTAC (proteolysis-targeting chimera) molecule that targets PARP1/2. It induces the degradation of PARP1 and PARP2 with DC50 values of 36 nM and 63 nM, respectively, and has IC50 values of 69 nM and 21 nM. This compound features a PARP inhibitor moiety derived from Veliparib, linked to the CRBN E3 ligase complex; Thalidomide acts as the ligand to recruit the CRBN E3 ubiquitin ligase, facilitating the degradation of PARP2.

Key Properties

• CAS Number: 2472645-27-3
• MW: 807.89
• Formula: C₄₀H₅₃N₇O₁₁
• SMILES: O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCOCCOCCOCCOCCOCCOCCN4[C@](C)(CCC4)C=5NC=6C(N5)=CC=CC6C(N)=O
• Target: PARP,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PARP,PROTACs