Ivangustin

SKU: orb1682300

Description

Ivangustin is a sesquiterpene lactone isolated from Inula britannica, demonstrating potent cytotoxic activity against human cancer cell lines including HEp2, SGC-7901, and HCT-116 in vitro. It serves as a valuable research tool for investigating anticancer mechanisms and sesquiterpene lactone biology.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 14164-59-1
• MW: 248.32
• Purity: 99.86% (May vary between batches)
• Formula: C₁₅H₂₀O₃
• SMILES: C[C@]12C(C[C@]3([C@@](C1)(OC(=O)C3=C)[H])[H])=C(C)CC[C@H]2O
• Target: PARP

Bioactivity

• In Vitro:
  In a Sulforhodamine B (SRB) colorimetric assay, Ivangustin exhibits cytotoxicity against HeLa, PC-3, Hep-2, HepG2, CHO, and HUVEC cells with IC50 values of 3.2 μM, 4.5 μM, 3.3 μM, 5.2 μM, 6.4 μM, and 9.2 μM, respectively.
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Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture,store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ivangustin, PARP

Compound Identifiers

PubChem CID

13895670