Ivachtin

SKU: orb1309533

Description

Ivachtin (Caspase-3 Inhibitor VII) is a potent, reversible, and noncompetitive small-molecule inhibitor of caspase-3 (IC50=23 nM) with lower activity against other caspases. This cell-permeable compound is widely used in vitro to study apoptotic pathways and has been applied in vivo within animal models of neurological and liver diseases.

Research Area

Cell Biology, Protein Biochemistry

Key Properties

• CAS Number: 745046-84-8
• MW: 447.46
• Purity: 99.74% (May vary between batches)
• Formula: C₂₀H₂₁N₃O₇S
• SMILES: O=C1C=2C=3C(N=C(C)C2C(=O)N1CCOC(C)=O)=CC=C(S(=O)(=O)N4CCOCC4)C3
• Target: Caspase
• Solubility: DMSO:slightly soluble;DMF:2 mg/mL (4.47 mM)

Bioactivity

• Target IC50:
  Caspase-3:23 nM
• In Vitro:
  Ivachtin has protective effect in a model of staurosporininduced apoptosis in human Jurkat T cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

apoptosis, caspases, Caspase-3, Caspase-3 Inhibitor VII, Caspase, modest, inhibit, Ivachtin, nonpeptide, noncompetitive, Inhibitor, selectivity, reversibl, staurosporininduced

Compound Identifiers

PubChem CID

11201705