IU1-47

SKU: orb1308181

Description

IU1-47 is a potent and selective inhibitor of the deubiquitinase USP14 (IC50 = 0.6 µM) with weaker activity against IsoT/USP5 (IC50 = 20 µM). It promotes tau clearance in neuronal cultures and is a valuable research tool for studying proteasome function, protein aggregation, and neurodegenerative disease models in vitro.

Research Area

Cell Biology, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 670270-31-2
• MW: 330.85
• Purity: 98.94% (May vary between batches)
• Formula: C₁₉H₂₃ClN₂O
• SMILES: Cc1cc(C(=O)CN2CCCCC2)c(C)n1-c1ccc(Cl)cc1
• Target: DUB
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.02 mM);DMSO:9 mg/mL (27.2 mM)

Bioactivity

• Target IC50:
  IsoT/USP5:20 μM|USP14:0.6 μM
• In Vitro:
  IU1-47 stimulates tau degradation principally via the ubiquitin-proteasome system. IU1-47 is essentially inactive on free USP14. IU1-47 (25 μM) antagonizes USP14 deubiquitinating activity and stimulates substrate degradation in vitro. IU1-47 (3 μM, 10, and 30 μM; 48 hours) obviously reduces Tau and phosphatase species Ser-202/Thr-205 levels in murine cortical primary neurons.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

USP14, Deubiquitinase, DUBs, Inhibitor, IU147, IU-1-47, IU1 47, IU1-47, inhibit, IsoT/USP5

Compound Identifiers

PubChem CID

675477