ITRI-90

SKU: orb3177255

Description

ITRI-90 is an orally active androgen receptor (AR) PROTAC degrader. It effectively degrades full-length AR (AR-FL) and its splice variant AR-V7 proteins via the ubiquitin-proteasome system, thereby inhibiting AR transcriptional activity and its target gene expression. This compound significantly suppresses the proliferation of prostate cancer cells, including those resistant to Enzalutamide, and induces apoptosis. ITRI-90 demonstrates favorable pharmacokinetic properties and exhibits strong antitumor efficacy in vivo, making it valuable for prostate cancer research.

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2798907-16-9
• MW: 908.06
• Formula: C₄₅H₅₆F₃N₉O₆S
• SMILES: C(F)(F)(F)C=1N2C(CCC(=N2)N3CCC(CC3)C4=CC=C(OCCCCOCC(N[C@H](C(=O)N5[C@H](C(NCC6=CC=C(C=C6)C7=C(C)N=CS7)=O)C[C@H](O)C5)C(C)(C)C)=O)C=C4)=NN1
• Target: PROTACs,Apoptosis,Androgen Receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PROTACs,Apoptosis,Androgen Receptor